EVALUATION OF CURATIVE EFFECT OF CELLULASE ASSISTED EXTRACTS OF FRESH AND BLACK GARLICS ON LIVER FIBROSIS MODEL INDUCED BY THIOACETAMIDE

Abstract

Garlic is one of the most popular spices and medicinal plants over the world. Beneficial effects of black garlic, a well-known poccessed product of garlic, for treatment chronic disease have been proved in several recent studies. The previous study proves that cellulase assisted extraction improves the polyphenol content and antioxidant capacity of garlic extract. However, the curative effect of cellulase assisted extracts of fresh and black garlics on liver fibrosis has not been elucidated yet. In this study, we used thioacetamide (300 mg/L for 10 weeks) to establish liver fibrosis model and evaluated beneficial effects of cellulase assisted extracts of fresh and black garlics on hepatic fibrosis model. The results showed that both cellulase assisted extracts of fresh and black garlics exhibited hepatoprotective effect on fibrosis model induced by thioacetamide and improved the alteration of thioacetamide on plasma biochemical parameters (ALT, AST, ALB) and liver hydroxyproline content, histological structure of liver. On the other hand, this study suggests that cellulase assisted extract of black garlic has stronger curative effect than cellulase assisted extract of fresh garlic, and cellulase assisted extract of black garlic is the prominent remedy for treatment liver fibrosis.