GENERATING AND EVALUATING HIGH FAT DIET - INDUCED OBESITY SWISS ALBINO MICE MODEL

Abstract

Obesity is a complex and chronic disease, so it is difficult to study issues related to obesity for a long time. Therefore, some of high fat diet-induced obesity animal models have been created and developed, providing valuable information about pathogenesis and treatment solutions for obesity. In this study, we used Swiss albino mice that were divided into two experimental groups and followed for 24 weeks: the group eating a low-fat diet (Normal group - CTL) and a high-fat diet (HFD). Results showed that daily calories from fat intake, weight and the body fat ratio of HFD group was higher than that of CTL group. At week 16 of the experimental period, the HFD group showed the total cholesterol, uric acid, ALT and AST were higher than that of the CTL group, and also showed macrovesicular steatosis formation. In conclusion, obesity model from Swiss albino was established which played an important key for researching and developing obesity treatments.