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Automation in Industry 4.0 brings about strong competitiveness, which will attract more businesses to join this revolution. As a result, the demand for human resources will fall drastically for automatable jobs which involve fixed procedures or rote memorization that can be performed by machines. Meanwhile, the emergence of new technologies will increase the demand for manpower in non-procedural tasks, which require flexibility and creativity. The forecasted employment outlook of graduates from the Industrial University of Ho Chi Minh City under the impact of Industry 4.0 shows that the university needs to have a clear orientation toward the structural shifts in labour demand, establish a human resource training program that focuses on the ability to carry out non-routine tasks, while fostering creativity, leadership skills, adaptability to changes in open work environments, thus ensuring graduates achieve higher skill levels and contribute to the national labour market to keep up with the coming era.