CHARACTERIZATION OF SYNERGISTIC EFFECT OF UNTI-K AND NANOCURCUMIN ON TREATMENT OF BREAST CANCER IN MICE

Abstract

Breast cancer is a malignant disease which is developed from epithelium of mammary gland. When the mammary gland is stimulated by a carcinogen, mammary gland cells is unregulated and unorganized proliferation leading to tumor formation. Unti-K is a medicinal product made from natural herbs, including Panax notoginseng powder, extracts dry of phylamin, extracts dry of Celastrus hindsii Benth, extracts of Allium sativum, , extracts of Crinum latifolium … contains saponin, flavonoid, S-allyl-L-Cystein, alkaloid… which cause cytotoxic effect to cancer cells, alkylation of nucleotides, prevention of DNA replication, delay in metastasis process of  cancer cells. Nanocurcumin has anti-angiogenesis effect and activates anti-cancer protein. Curcumin is protected  in nano form and facilitated to move to the target cell. In this study,  we have established a prevention and treatment model for breast cancer induced by DMBA with characterization of unti-k and nanocurcumin on mice (Mus musculus var. Albino). After 40 weeks of prevention and treatment, body weight index and white blood cell counts of mice has recovered to normal condition. Effectiveness of combination of unti-k and nanocurcumin for the reduction of tumor volume has been proven. Histological analysis showes that  unti-k and nanocurcumin have inhibited the invasion of breast cancer cell tissue in the surrounding tissue or the adipose tissue, stroma tissue, and necrotizing tissue has gradually recovered. So, combination of unti-k and nanocurcumin has created a microscopic particle size, helps to quickly absorb substances into the blood resulting to increases the amount of T lymphocytes, recovers immune system, prevents  proliferation, and inhibit metastases, accelerates the death of cancer cells.