DOMINANT ATTRIBUTIONS PHENOLIC COMPOUNDS IN LEPIDAGSTHIS THORELII EXTRACTS RESPONDING FOR ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES

Abstract

Extracts from some species in the genus Lepidagathis have demonstrated biological activities such as antifungal, anti-inflammatory, antioxidant, and insecticidal propertie. Lepidagsthis thorelii is a species widely spreading from tropical to subtropical regions, however no research has been published on the antioxidant properties of this plant species until now. This study evaluated the TPC, phenolics, antioxidant, and antimicrobial activity of extracts from two L. thorelii parts by four extract solvents (methanol, ethanol, acetone, methylacetate). The methanol extracts obtained the highest TPC. Two methanol L. thorelii extracts and two acetone L. thorelii extracts with the relevant IC50 values (0.35, 0.39, 0.37, and 0.26 mg/mL) possessed remarkable properties of scavenging reactive oxygen species. The antioxidant capacities in three extracts indexed good correlations with their TPC values, except the L. thorelii flower. Methanol extracts revealed impacts to the growth of B. subtilis, and E. coli. The study confirmed extracts from L. thorelii provide potential phenolic compounds for antioxidant therapeutic applications or antimicrobial activity of L. thorelii extracts. This study first reported the presence of HBA and ferulic in L. thorelii as molecular indicators to understand the antioxidant potential of L. thorelii.