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The paper was presented simulation results of single-stage vapor-compression refrigeration system. Parameters of refrigerant and refrigeration cycle uses R22, R410A and R32 refrigerants based on Matlab/Simulink software. The system was simulated with a cooling capacity of 9000 BTU/h (2,638 kW), evaporation temperature was 50 C and condensation temperature was 400 C. The simulation process has determined the state parameters and the temperature affection which impacted on the single-stage refrigeration system. The simulation results are achieved at the same operating temperature and equivalent cooling capacity to compressor displacement uses R22 refrigerant higher 31%, 37% than R410A/R32 and the Coefficient of Performance (COP) are 5,581 (R22)/5,177 (R410A)/5,396 (R32).